Sunday, 23 June 2019

Autoimmunity and chair-side risk assessment of temporomandibular disorders

At the 97th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 48th Annual Meeting of the American Association for Dental Research (AADR) and the 43rd Annual Meeting of the Canadian Association for Dental Research (CADR), many oral and poster presentations centered around temporomandibular disorders, or TMD. The IADR/AADR/CADR General Session & Exhibition is held at the Vancouver Convention Centre West Building in Vancouver, BC, Canada from June 19-22, 2019.

* This article was originally published here

A new drug target for chemically induced Parkinson's disease

More than three decades ago, scientists discovered that a chemical found in a synthetic opioid, MPTP, induced the onset of a form of Parkinson's disease. In a new study led by scientists from the School of Veterinary Medicine, researchers found that an enzyme in the body can metabolize compounds formed in the brain from alkaloids present in certain foods and tobacco into MPTP-like chemicals, triggering a neurodegenerative condition in mice.

* This article was originally published here

Embryonic microRNA fuels heart cell regeneration, researchers show

By adulthood, the heart is no longer able to replenish injured or diseased cells. As a result, heart disease or an event like a heart attack can be disastrous, leading to massive cell death and permanent declines in function. A new study by scientists at the Lewis Katz School of Medicine at Temple University (LKSOM), however, shows that it may be possible to reverse this damage and restore heart function, even after a severe heart attack.

* This article was originally published here

UK study shows seal singing 'Twinkle, Twinkle, Little Star'

Researchers in Scotland say gray seals can copy the sounds of human words and songs including "Twinkle, Twinkle, Little Star."

* This article was originally published here

Toward artificial intelligence that learns to write code

Learning to code involves recognizing how to structure a program, and how to fill in every last detail correctly. No wonder it can be so frustrating.

* This article was originally published here

Major HIV drug requires vigilance, study says

A study lead by researchers at the Institute of HIV Research, Medical Faculty of UDE and University Hospital Essen reports a potential toxicity of integrase inhibitors. Integrase inhibitors (INSTI) are a preferred drug for inclusion in anti-retroviral therapy regimens given its tolerability, efficacy and high resistance barrier. INSTI have been found to improve and prolong lives of millions of people living with HIV who suffer side-effects and resistance to treatment. However, recent laboratory data suggest that INSTI may not be as safe as suggested.

* This article was originally published here

Using game theory to model poisoning attack scenarios

Poisoning attacks are among the greatest security threats for machine learning (ML) models. In this type of attack, an adversary tries to control a fraction of the data used to train neural networks and injects malicious data points to hinder a model's performance.

* This article was originally published here

Hydrogen-natural gas hydrates harvested by natural gas

A hydrogen-natural gas blend (HNGB) can be a game changer only if it can be stored safely and used as a sustainable clean energy resource. A recent study has suggested a new strategy for stably storing hydrogen, using natural gas as a stabilizer. The research proposed a practical gas phase modulator based synthesis of HNGB without generating chemical waste after dissociation for the immediate service.

* This article was originally published here

Dry lakebeds and fights for water as drought grips India's Chennai

Angry residents fight in queues at water taps, lakes have been turned into barren moonscapes and restaurants are cutting back on meals as the worst drought in living memory grips India's Chennai.

* This article was originally published here

New e-tattoo enables accurate, uninterrupted heart monitoring for days

The leading cause of death in Texas is heart disease, according to the National Center for Health Statistics, accounting for more than 45,000 deaths statewide in 2017. A new wearable technology made from stretchy, lightweight material could make heart health monitoring easier and more accurate than existing electrocardiograph machines—a technology that has changed little in almost a century.

* This article was originally published here

Exposure to others' suffering even worse than being shot at

We usually think that trauma from war is related to the fact that soldiers have been under constant threat of death. New research shows a slightly different picture.

* This article was originally published here

Gender-specific differences in the salivary microbiome of caries-active children

At the 97th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 48th Annual Meeting of the American Association for Dental Research (AADR) and the 43rd Annual Meeting of the Canadian Association for Dental Research (CADR),

* This article was originally published here

Advanced computational modeling of the gut for biodefense

The Nutritional Immunology and Molecular Medicine Laboratory (NIMML) has developed a high-resolution model of the gut immune system by using advanced computational systems. The new high-performance computing (HPC)-driven model of the gut predicts new emerging behaviors and responses to biological threats. The gut ecosystem includes trillions of interactions between host epithelial and immune cells, molecules (cytokines, chemokines and metabolites) and microbes is a massively and dynamically interacting network, similar to a multidimensional jigsaw puzzle with pieces that are constantly changing shape. These interactions with cooperativity and feedback lead to nonlinear dynamics and unforeseen emergent behaviors across spatiotemporal scales. The NIMML model of the gut facilitates discovering new knowledge within this complex system for biodefense applications.

* This article was originally published here

Mystery of immunosuppressive drug's biosynthesis finally unlocked

Mycophenolic acid (MPA), discovered in 1893, was the first natural antibiotic to be isolated and crystallized in human history. Today, this fungal metabolite has been developed into multiple first-line immunosuppressive drugs to control immunologic rejection during organ transplantation and treat various autoimmune diseases.

* This article was originally published here